DEP System

The DermoElectroPoration® System is a Class II FDA cleared biophysical alternative to infuse high weight molecule modalities into the dermis without the use of needles!  DEP Medical is the exclusive North American distributor of Transderm® Infusion.

DermoElectroPoration® (DEP) is a patented, proprietary technology from Mattioli Engineering. It utilizes the skins water based “channels” to allow ionic drug solutions to penetrate due to controlled “electroporation-like” continuous reversed polarity electrical pulses. Because of this, DermoElectroPoration® is able to control the average pulse value and vary the pulse shape according to the skin’s specific electrical impedance.

It promotes the transdermal delivery of both micro- and macro molecules (up to 2 million Dalton weight) safely into the body without the need of modifying the ionic drug solution pH, as with traditional iontophoresis. DermoElectroPoration® does not require a pH compensation patch, driving gels, or pre-charged ions.

Unlike traditional iontophoresis, DermoElectroPoration® does not have an electrolysis reaction at the site of the electrodes. There is no degradation of the molecule being delivered. This means that both positive and negative ions of the drug are delivered into the body – the drug is delivered as a whole.